منابع مشابه
So do we understand how enzymes work?
Between 1930 and 1975 biochemical and structural analysis of enzymes led to a clear set of ideas that might form a basis for detailed understanding of enzyme action. Further development required energetic and thermodynamic analysis of enzymes in an aqueous medium, beyond the computational power then available. Structural enzymology advanced in other directions, but the fundamental questions of ...
متن کاملHow do enzymes work?
The principle of transition-state stabilization asserts that the occurrence of enzymic catalysis is equivalent to saying that an enzyme binds the transition state much more strongly than it binds the ground-state reactants. An outline of the origin and gradual acceptance of this idea is presented, and elementary transition-state theory is reviewed. It is pointed out that a misconception about t...
متن کاملHow do enzymes really work?
My understanding is that “reflections” can cover a multitude of sins. I have previously written a brief history of my career, and do not want to duplicate that exposition (1). Instead, this “reflection” will trace a primary focus of my laboratory for many decades, namely how do enzymes achieve their remarkable catalytic efficiency? (Indeed this has been a focal point of the field of biochemistr...
متن کاملHow do We Understand other Humans?
In last two decades we had an intense discussion about which theory best describes how we understand other human beings. I will argue that neither Simulation Theory nor TheoryTheory nor Interaction-Theory do offer us an adequate analysis. Despite the fact that they highlight some relevant aspects, the generalization made by each theory cannot do justice to the varieties of social understanding ...
متن کاملHow well do we understand cosmological recombination?
The major theoretical limitation for extracting cosmological parameters from the CMB sky lies in the precision with which we can calculate the cosmological recombination process. Uncertainty in the details of hydrogen and helium recombination could effectively increase the errors or bias the values of the cosmological parameters derived from the Planck satellite, for example. Here we modify the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Structure
سال: 2000
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(00)00125-8